Cancer Paradigm Series
A visual research collection in Cellular Physiology and Biochemistry presenting the Epistemology of the Origin of Cancer: from chronic inflammation and fibrosis to pre-cancerous niches, chronic stress escape strategy, first cancer cell formation and pre-metastatic niches.
About this Collection
The Cancer Paradigm Series brings together concepts from epithelial cancer biology, tumor microenvironment research, chronic inflammation, fibrosis, extracellular matrix remodeling, epithelial-mesenchymal plasticity, cancer-associated fibroblasts, immune modulation and pre-metastatic niche formation.
This page serves as a visual entry point into the series. It does not replace the full peer-reviewed articles, but helps readers follow the conceptual development across the published parts and related publications.
Development of the Series
2014
Initial model linking pathogenic stimulus, chronic inflammation, fibrosis, extracellular matrix remodeling and the emergence of a pre-cancerous niche.
2019
Further development of the signaling framework and cellular crosstalk connected to the original cancer paradigm.
2023
Expansion toward chronic stress escape strategy, EMT/MET, cancer-associated fibroblasts and proposed first cancer cell formation.
2025
Extension from pre-cancerous niche to PMN-1, PMN-2 and PMN-3, including motility, immune modulation, extracellular matrix gradients and cancer satellites.
Series Articles and Related Publications
Part I
Cancer Paradigm I
The initial CPB article presenting the first cancer paradigm and the role of chronic inflammation, fibrosis and pre-cancerous niche formation.
Related 2014 Article
Related publication on the original paradigm
Additional publication related to the original model and conceptual development of the cancer paradigm.
2019 Update
Updated signaling and crosstalk
Updated framework describing additional signaling and cellular crosstalk five years after the original paradigm.
Part II
First Cancer Cell
The second part focuses on chronic stress escape strategy, EMT/MET, cancer-associated fibroblasts and proposed formation of the first cancer cell.
Part III
Pre-Metastatic Niches
The third part extends the framework toward PMN-1, PMN-2 and PMN-3, including cancer satellites, immune evasion and dissemination.
Graphical Highlights
Ongoing and Future Directions
The Cancer Paradigm Series may continue with further conceptual and graphical development, including additional mechanisms related to epithelial cancer origin, tumor microenvironment evolution, pre-metastatic niche formation and metastasis.
CPB welcomes mechanistic, translational and conceptual contributions related to tumor microenvironment biology, fibrosis, cancer-associated fibroblasts, pre-metastatic niches and integrative cancer physiology.
Frequently Asked Questions
It is a multi-part integrative framework discussing epithelial cancer origin, chronic inflammation, fibrosis, pre-cancerous niches and pre-metastatic niche formation.
No. This page is a visual entry point and overview. Readers should consult the full peer-reviewed articles for detailed arguments, mechanisms and references.
They help readers quickly follow the stepwise conceptual development from inflammation and fibrosis to PMN formation and metastasis-related mechanisms.